BHP Billiton will move more than 3,000 staff into its newly completed office tower in Perth by October.
Despite ongoing speculation, the mining giant insists its global headquarters will remain in Melbourne.
Over the next few months Australia's biggest company plans to bring its Perth-based iron ore, aluminium and nickel headquarters under the one roof.
BHP also hopes to quash, once and for all, rumours that it could move its headquarters from Melbourne to the resources hub of Perth.
A BHP Billiton spokeswoman said more than 3,000 employees were moving in a in stages from multiple Perth offices into Brookfield Place, at 125 St George's Terrace.
"Everyone will be in there sometime during the third quarter of this calendar year," the spokeswoman told AAP.
"BHP Billiton is not relocating its Australian headquarters to Perth.
"We are consolidating our staff who are in different buildings across Perth."
As well as securing the naming rights to the new 45 storey skyscraper, BHP has agreed to lease at least 75 per cent of the premises.
But it has no intention of purchasing the property, billed as the largest commercial building in Western Australia.
Brookfield Multiplex completed construction of the 234 metre, 86,000 square metre Brookfield Place in late May and it plans to open the building around mid-September.
BHP has also decided to secure a new lease at 171 Collins Street in Melbourne, dealing a blow to the City of Perth which wanted to attract more executives and professionals to the growing CBD.
CMC Markets chief market strategist Michael McCarthy said there were no compelling reasons for BHP to stay in Melbourne.
"My guess is BHP will move their Australian headquarters to Perth," Mr McCarthy said.
It comes after the company's chief executive Marius Kloppers told a Perth breakfast on Wednesday that it was harder to convince east coast Australians to relocate for work than North Americans, particularly with the high cost of living.
But Perth Lord Mayor Lisa Scaffidi said she understood the comments to be in relation to fly-in, fly-out workers in the Pilbara.
Meanwhile, Barrick Gold and PwC are preparing to occupy the remaining space at Brookfield Place.
One of the conditions of the BHP Billiton merger in 2001 was that the company's headquarters would remain in Australia.
